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Iron and Ferritin FAQ

NOTE: THIS FAQ CAN BE SENT TO MEMBERS ONLY. HOWEVER, OUR INTENT IN PROVIDING THIS INFORMATION IS TO EDUCATE OUR CUSTOMER SERVICE REPS ABOUT THE COMPLEX INTER-RELATIONSHIPS AMONG MINERALS AND HOW THEY FUNCTION WITHIN THE BODY.

5:13: 1. IRON AND COPPER

Research on iron overload points to iron being free in the blood stream and not bound properly to carrier proteins. This unbound iron is called uncontrolled iron.

 

http://www.irondisorders.org/absorption/  Transferrin is the major transporter of iron and ideally should be about 25-35% saturated with iron. Transferrin molecules that are fully saturated lose the ability bind iron. Unbound or free iron is highly destructive and dangerous; it can trigger free radical activity, which can cause cell death, and destroy DNA.

 

Free iron can provide nourishment for bacteria such as Yersinia, Listeria and Vibrio. These bacteria are harmless for people with normal iron levels, but when transferrin is highly saturated with iron Yersinia,  Listeria, and Vibrio, contained in raw shellfish such as oysters, can lead to serious infection.

 

'There is an anemia of chronic disease that some people with autoimmune disease get – RA for example to keep bacteria from feeding off free iron. In these cases, iron will be low but ferritin will be high to store iron out of the reach of bacteria.

 

 The back up mechanism for keeping iron bound is Ceruloplasmin.  Cp is a ferroxidase enzyme that in humans is encoded by the CP gene. Ferroxidase means that it’s got iron in its structure. It carries copper and it binds and carries iron. Iron needs copper to reach the brain and it needs Cp to help keep iron from being toxic.

 

Part of the problem with iron overload and ferritin excess is that the ways that ceruloplasmin levels can be depleted which results in free iron overload.

 

The list is long:

 

  1. Vit D can deplete it yet Cp requires Vit A for production but you need some Vit D to keep Vit A balanced. (THAT’S WHY I RECOMMEND OMEGA-3 ALGAE A+E)

 

  1. Stress depletes Ceruloplasmin. THAT’S WHY I RECOMMEND REMAG TO DECREASE THESE STRESS REACTIONS THAT LEAD TO CHEMICAL CHANGES IN THE BODY.

 

Looking at those pathways is pretty fascinating. Cp is diminished by the production of ACTH under stress, which will stop the production of ceruloplasmin in the liver and in the brain. When ACTH is high magnesium is low and vice versa.

 

(Reference: http://www.vivo.colostate.edu/hbooks/pathphys/endocrine/hypopit/acth.html)

 

Corticotropin-releasing hormone from the hypothalamus is secreted in response to many types of stress – physical, chemical, emotional and makes ACTH – adrenocortocostimulating hormomine that triggers production of glucocorticoids Glucocorticoids are anti-inflammatory and immune suppressive. (cortisol – synthetic cortisol is called hydrocortisone). It is involved in the functioning of proper glucose metabolism, as well as the regulation of blood pressure, insulin release for blood sugar maintenance and the inflammatory response- so that’s why stress can help create DM, high BP, and autoimmune disease.) Cortisol production is shut off when there is a certain level in a negative feedback loop. 

 

As a sidebar: Within the pituitary gland, ACTH is produced in a process that also generates several other hormones. A large precursor protein named pro-opio-melano-cortin (POMC, "Big Mama") is synthesized and chopped into several fragments that include:

  1. Lipotropin: Originally described as having weak lipolytic effects, its major importance is as the precursor to beta-endorphin. (Lipolysis/lᵻˈpɒlᵻsɪs/ is the breakdown of lipids and involves hydrolysis of triglycerides into glycerol and free fatty acids.)
  2. Beta-endorphin and Met-enkephalin: Opioid peptides with pain-alleviation and euphoric effects. (This is what athletes are trying to produce with the stress of their physical activity.)
  3. Melanocyte-stimulating hormone (MSH): the production and release of melanin which controls pigmentation in the skin. Hyperpigmentation in pregnancy, Cushings disease and Addison’s disease. THE NEXT FEW CAUSES OF DIMINISHING CP HAS TO DO With COPPER DEFICIENCY. MY TREATMENT IS HAVING BIOAVAILABLE COPPER IN REMYTE IN THE CORRECT PROPORITION With ZINC. PEOPLE TALK ABOUT COPPER TOXICITY FROM WATER PIPES, BCP, AND COPPER IN THE ENVIRONMENT. BUT THAT’S NOT BIOAVAILABLE COPPER.
  4. Zinc supplements lower copper levels. If you’ve been consuming zinc supplements for a long time then you might be copper deficient, and vice versa. Ask your doctor about the zinc to copper ratio, but it’s about ten to one.AGAIN, REMYTE HAS 300 MICROGRAMS OF BIOAVAILABLE COPPER. MOST SUPPLEMENTS ARE 2,000-3,000micrograms. The whole balance of minerals in ReMyte is important.
  5. High Fructose Corn Syrup causes copper deficiency, which will diminish the production of ceruloplasmin. You need copper to make ceruloplasmin. (https://www.westonaprice.org/health-topics/modern-foods/the-double-danger-of-high-fructose-corn-syrup/) And the pediatric endocrinologist’s youtube about Sugar: The Bitter Truth: Dr. Robert Lustig: https://www.youtube.com/watch?v=dBnniua6-oM The US Department of Agriculture investigated the harmful effects of dietary sugar on rats. They discovered that when male rats are fed a diet deficient in copper, with sucrose as the carbohydrate, they develop severe pathologies of vital organs. Liver, heart and testes exhibit extreme swelling, while the pancreas atrophies, invariably leading to death of the rats before maturity. Sucrose is a disaccharide composed of 50 percent glucose and 50 percent fructose. Dr. Fields repeated her experiments to determine whether it was the glucose or fructose moiety that caused the harmful effects. When the rats were fed fructose, the fatal organ abnormalities occurred.  Lysl oxidase is a copper-dependent enzyme that participates in the formation of collagen and elastin. Fructose interferes with copper metabolism to such an extent that collagen and elastin cannot form in growing animals. These experiments should give us pause when we consider the great increase in the use of high fructose corn syrup during the past 30 years, particularly in soft drinks, fruit juices and other beverages aimed at growing children, children increasingly likely to be copper deficient as modern parents no longer serve liver to their families. (Liver is by far the best source of copper in human diets.) “The bodies of the children I see today are mush,” observed a concerned chiropractor recently. The culprit is the modern diet, high in fructose and low in copper-containing foods, resulting in inadequate formation of elastin and collagen–the sinews that hold the body together.
  6. Copper deficiency will make your blood vessels lose elasticity and rupture easily. I TALK ABOUT THIS IN MAGNESIUM MIRACLE.
  7. Resveratrol supplements are drug muggers of copper. THIS IS FROM SUZY COHEN’S BLOG ON COPPER: Resveratrol is a type of natural phenol, produced by several plants in response to injury or, when the plant is under attack by pathogens such as bacteria or fungi.[5][6] Sources of resveratrol in food include the skin of grapes, blueberries, raspberries, mulberries.[7]
  8. Copper is needed to make melanin, so deficiencies are often seen in people with premature grey hair. 
  9. Cardiac arrhythmias can result from low copper status. Copper depletion experiments with men and women have revealed abnormalities of lipid metabolism, blood pressure control, and electrocardiograms plus impaired glucose tolerance.
  10. A marker for low copper is elevated histamine levels. And mast cells and histamine become elevated in magnesium deficiency. Anti-histamine enzymes require copper, magnesium and vitamin B6 for them to work. They all have to be balanced.

MY TREATMENT IS REMAG AND THE METHYLATED B’S IN REALINE.

WHY COPPER IS IMPORTANT:

Copper is required for the formation of about 50 enzymes and copper is part of the transport proteins that shuttle hormones and neurotransmitters all over your body. Copper protects the lining of blood vessels and myelin. It supports energy production. It supports the healthy functioning of two major enzymes in your body, one is SOD and the other is DAO.

SOD = superoxide dismutase: This enzyme repairs cells and keeps them from getting killed by superoxide! SOD protects mitochondria, and has anti-cancer activity. Without adequate levels of the enzyme SOD you will likely get cardiovascular disease. Copper helps increase SOD.

DAO = diamine oxidase: This enzyme breaks down histamine from all the foods you eat. There are hundreds of foods that contain histamine (it can cause migraines by the way). DAO is your body’s natural anthistamine. Copper increases activity and functioning.

If you have iron deficiency anemia that doesn’t respond to iron supplementation, and you’re ferritin remains suppressed, you might be copper deficient. You need iron to make hemoglobin, the main component of red blood cells and you cannot absorb iron without copper. Long story short, copper deficiency is sometimes at the heart of resistant iron deficiency anemia. An “RBC copper” blood test can reveal this

RnA ReSet Drops and ReStructure will also be helpful because all these enzymes in the body are proteins and require good building blocks like RnA ReSet Drops and ReStructure.